Projects
Application of mass spectrometers in medicine
For medical applications, the Scientific Instruments JSC company has developed portable mass spectrometers "Micropor" and "Micropor-M" with membrane sample introduction.
The mass spectrometers are designed for:
- Determination of toxic substances in the rapid diagnosis of poisoning based on the analysis of the composition of exhaled air
- Analysis of the gas mixture in the breathing circuit of the inhalation anesthesia machine during surgical operations
- Determination of drugs in biological fluids
Operation principle
The mass spectrometers are based on a quadrupole mass analyzer with a mass number measurement range from 1 to 300 amu. The analyzer rods are 100 mm long. The instruments use a closed electron impact ion source. Ion detection is carried out by a secondary electron multiplier (SEM).
The mass spectrometers provide continuous spectrum scanning in a given mass range, and also real-time trend analysis of substances with continuous measurement of selected spectral peaks.
The working pressure in the vacuum chamber during the analysis is about 10-5 mm Hg. The sample introduction unit is equipped with an internal shut-off valve that allows the membrane to be changed without breaking the vacuum in the instrument. To increase the threshold sensitivity of the instruments, a "direct" introduction of the analyzed gas from the membrane into the region of the ion source is used.
The sample is introduced through a hydrophobic selective membrane that has increased permeability to organic gas components of microimpurities of the analyzed medium (air or liquid).
Technical characteristics of the "Micropor" mass spectrometer
Range of measured mass numbers | 1 - 300 amu |
Resolution at 10% of peak height | 0.5 - 2.5 amu |
Detection limits | 0.01 - 10 ppm |
Maximum working pressure | 1×10-4 torr |
Supply voltage | 220 V, 12 - 36 V |
Continuous working time | not less than 6 hours |
Battery capacity | 14 A•h |
Weight | 24 kg |
Dimensions | 500 х 305 х 457 mm |
Technical characteristics of the "Micropor-M" mass spectrometer
Range of measured mass numbers | 1 - 300 amu |
Resolution at 10% of peak height | 0.5 - 2.5 amu |
Detection limits | 0.01 - 10 ppm |
Maximum working pressure | 1×10-4 torr |
Supply voltage | 220 V |
Power consumption | not more than 70 W |
Weight | 29 kg |
Dimensions | 510 х 220 х 390 mm |